BelleNAD+
BelleNAD⁺ is a next-generation bioactive skin booster centered on NAD⁺-driven cellular energy activation to restore dermal vitality and skin resilience. Its advanced formulation combines NAD⁺ and its metabolic precursor NMN with PN and PDRN, multi-molecular hyaluronic acid, and the proprietary Complexia 55™ nutrient matrix.
This synergistic approach enhances cellular metabolism, supports regeneration, and revitalizes fatigued, biologically aged skin from within.
KEY BENEFITS
Restores dermal density, elasticity, and firmness.
Safe, sterile, and designed for professional regenerative protocols.
Enhances cellular energy and metabolic activity.
Provides deep, layered hydration and improved skin resilience.
Accelerates recovery in stressed or post-procedural skin.
SCIENTIFIC FOUNDATION
BelleNAD+ is built on the central role of NAD+ in cellular energy metabolism and skin homeostasis. As a key regulator of mitochondrial function, NAD⁺ supports ATP production, redox balance, and DNA repair, all of which are essential for cellular renewal and resistance to oxidative stress. The inclusion of NMN sustains intracellular NAD⁺ availability, helping restore metabolic activity in aging and energy-depleted skin cells.
PN and PDRN complement this bioenergetic core by stimulating fibroblast activity and extracellular matrix remodeling through adenosine A₂A receptor activation, promoting collagen synthesis and tissue regeneration.
Multi-molecular hyaluronic acid optimizes the dermal microenvironment by supporting hydration and viscoelastic balance, while Complexia 55™ supplies essential nutrients required for enzymatic function and sustained cellular efficiency, reinforcing long-term skin vitality.
HOW IT WORKS
Regeneration: PN and PDRN activate fibroblasts to support matrix renewal and tissue repair.
Hydration: Multi-molecular Hyaluronic Acid restores moisture, elasticity, and dermal comfort.
Recovery: Bioactive components modulate inflammation and support dermal repair.
Cellular Energy: NMN and NAD enhance mitochondrial function and metabolic balance.
For professionals
BelleNAD⁺ is supplied in 5 ml sterile vials and formulated at physiological pH (6.8–7.2) for seamless integration into advanced aesthetic protocols. Powered by TruActive™ Technology, it preserves ingredient activity and performance throughout treatment application.
Designed exclusively for medical and aesthetic professionals, BelleNAD⁺ offers distributors a differentiated, science-driven solution aligned with the growing demand for regenerative and longevity-focused aesthetics.
Ingredients
Main Actives:
NAD⁺
NucleoDuo® – a combination of Polynucleotides, PN and PDRN.
triHA™ – a blend of Hyaluronic Acid with three molecular weights.
Collagen III
Powered by Complexia 55®, a plasma-like nutrient-rich complex.
Indications
High-performance skin booster for cellular revitalization, metabolic activation, and dermal regeneration
BelleNAD⁺ is indicated for the management of skin conditions associated with impaired cellular energy metabolism, reduced regenerative capacity, and progressive dermal deterioration. It is particularly suited for clinical scenarios where restoration of biological skin function is required rather than volumization or filler-like effects.
Indications include
- Loss of dermal vitality, elasticity, and firmness related to intrinsic and extrinsic aging.
- Skin presenting signs of cellular fatigue, metabolic slowdown, or reduced regenerative response.
- Photoaged skin characterized by dullness, uneven texture, and compromised dermal quality.
- Dehydrated skin with altered viscoelastic balance and reduced tissue resilience.
- Atrophic or thin skin requiring metabolic and structural support.
- Environmentally stressed skin exposed to oxidative stress, pollution, or lifestyle-related damage.
- Post-procedural skin recovery following energy-based or regenerative treatments (laser, IPL, radiofrequency, microneedling).
- As a supportive treatment in combined protocols aimed at enhancing tissue response and optimizing clinical outcomes.
Treatment areas
Face, neck, décolleté.
Medical use
To be administered under medical supervision.
Medical INFO
BelleNAD+ is an advanced bioactive skin booster designed to address functional skin aging through targeted activation of cellular energy metabolism, DNA repair mechanisms, and dermal regeneration.
NAD⁺-Driven Bioenergetic Activation
The formulation is centered on NAD⁺ supplementation, addressing age- and stress-related depletion of intracellular NAD⁺ that compromises mitochondrial efficiency and cellular performance. By providing NAD⁺ together with its metabolic precursor NMN, BelleNAD⁺ supports intracellular NAD⁺ availability, enhancing mitochondrial activity, ATP generation, and cellular recovery in energy-depleted dermal cells.
Support of DNA Repair Pathways
Sustained NAD⁺ availability enables the activity of NAD⁺-dependent enzymes involved in DNA repair and cellular stress response. This supports recovery from oxidative and photo-induced damage and contributes to improved cellular stability in chronically stressed or aged skin.
Regenerative Signaling via PN and PDRN
PN and PDRN provide nucleotidic substrates that stimulate fibroblast activity and extracellular matrix remodeling. Their regenerative effects are mediated in part through adenosine A₂A receptor activation, promoting collagen synthesis, angiogenic response, and tissue regeneration, while supporting a controlled inflammatory environment.
Dermal Microenvironment Optimization
Multi-molecular hyaluronic acid supports dermal hydration, viscoelastic balance, and matrix organization, facilitating effective cellular signaling and improving overall tissue quality without volumization.
Metabolic Support with Complexia 55™
The formulation is reinforced by Complexia 55™, a proprietary nutrient matrix supplying amino acids, nucleotides, vitamins, antioxidants, and trace elements required for enzymatic activity and sustained metabolic efficiency, amplifying the bioenergetic and regenerative effects of the formulation.
Clinical Positioning
Through its metabolism-driven, non-volumizing mechanism of action, BelleNAD⁺ is positioned as a first-choice skin booster for physicians seeking to improve skin vitality, radiance, and regenerative capacity, either as a standalone treatment or as a foundational component of combined and device-based protocols.
BelleNAD+ delivers regenerative bioactive technology focused on dermal vitality and cellular energy renewal.
Contact Persebelle to integrate BelleNAD+ into your professional aesthetic protocols.
