Belle Revita – Regenerative Bioactive Solution for Deep Hydration & Barrier Repair
BelleRevita
Belle Revita peptide® is a peptide-enriched formula developed to provide intensive hydration and restore the skin barrier.
It replenishes water balance, enhances elasticity, and improves texture, making it a cornerstone solution for patients requiring revitalization and long-term hydration.
KEY BENEFITS
Deep, sustained skin hydration.
Safe, well-tolerated, and clinically evaluated.
Supports dermal nutrition and metabolic balance.
Promotes balanced water retention in tissues.
Reinforces epidermal barrier function.
Improves elasticity, softness, and texture.
SCIENTIFIC FOUNDATION
BelleRevita peptide® is designed to support skin hydration and metabolic balance by contributing to an optimized dermal microenvironment that favors physiological water homeostasis and cellular functionality. Rather than acting on isolated targets, the formulation supports the conditions required for regulated aquaporin-mediated water transport, structural protein stability, and efficient cellular metabolism.
By providing a nutrient-rich environment that supports membrane integrity and redox balance, the formulation contributes to controlled water distribution, dermal resilience, and barrier function, helping improve overall skin quality and promote a balanced, well-nourished complexion.
HOW IT WORKS
Supports AQP3-mediated keratinocyte water/ glycerol transport.
Enhances GAG-rich dermal ECM water retention.
Supports fibroblasts; maintains collagen I/III architecture.
Reinforces barrier lipids, tight junctions; reduces TEWL.
For professionals
A sterile, clinic-ready formulation designed for high-demand mesotherapy and microneedling protocols focused on intensive hydration and dermal nutrition. BelleRevita peptide® delivers a refined skin-quality approach—supporting barrier resilience, comfort, and visible improvement—positioned for strong performance in professional distributor portfolios.
Ingredients
Main Actives:
Complexia Forte 55™
Plasma-like, nutrient-rich complex of amino acids,
vitamins, nucleotides and co-factors supporting skin vitality
Hyaluronic Acid
DermalGen™ – Dermal Collagen I–III System
Homologous Collagen Type I & Type III
Dual Antioxidant System
Glutathione & α-Lipoic Acid
Indications
PROFESSIONAL HYDRATION & DERMAL NUTRITION
BelleRevita peptide® is intended for professional aesthetic practice in patients selected at physician discretion, where the clinical goal is to improve skin hydration status, dermal vitality, and overall skin quality via mesotherapy and/or microneedling.
Primary indications (skin quality)
- Dehydrated skin / reduced turgor, including seasonal or environmentally stressed skin
- Photoaged or early chronological aging skin, with fine lines, crepey texture, and reduced elasticity/firmness
- Compromised barrier function / increased transepidermal water loss profile, with tightness, roughness, and reduced skin comfort
- Dullness and uneven texture, for skin-quality maintenance indications
Clinical integration:
Suitable as a standalone skin-quality course or as an adjunct within combined aesthetic plans to optimize hydration, comfort, and treatment readiness, at physician discretion.
Treatment areas
Face, neck, décolletage, and hands.
Professional use
Application requires medical supervision.
Medical INFO
BelleRevita peptide® is a sterile, professional solution designed for mesotherapy and microneedling to support skin quality through hydration biology, dermal nutrition, barrier performance, and extracellular matrix (ECM) integrity.
TruActive Sense™ refers to a manufacturing approach based on aseptic processing and aseptic filling, formulated without added preservatives, to help maintain active integrity and ensure sterile presentation for professional use.
Mechanism of Action (physician-facing biologic rationale)
Dermal hydration reservoir and ECM rheology (Hyaluronic Acid)
Hyaluronic Acid acts as a high-capacity glycosaminoglycan water-binding network in the papillary dermis, improving ECM hydration, viscoelasticity, and turgor. The electrolyte/oligoelement system (Na⁺/K⁺/Cl⁻/phosphate/bicarbonate, Mg²⁺, Ca²⁺) supports physiologic ionic strength and osmotic balance, helping stabilize interstitial hydration following intradermal placement.Epidermal water homeostasis and aquaporin functionality (AQP3 axis)
Hydration quality depends on regulated transcellular water/glycerol transport, not only passive water binding. The peptide-enriched environment, together with metabolic cofactors and antioxidant support, contributes to keratinocyte membrane protein homeostasis, supporting consistent AQP3-mediated water/glycerol flux and balanced moisture distribution across epidermal layers.Barrier reinforcement and reduced TEWL profile (lipids + cohesion biology)
Barrier performance is governed by epidermal differentiation and cohesion structures (cornified envelope, corneodesmosomes, tight junctions, lipid lamellae). Niacinamide (Vit. B3) supports barrier lipid metabolism and skin comfort. Dexpanthenol / Pantothenic Acid (Vit. B5) and B-vitamin cofactors support cellular recovery and barrier normalization. Calcium and magnesium salts contribute to differentiation signaling and epidermal cohesion gradients, supporting improved barrier resilience and hydration retention.DermalGen™ – Dermal Collagen I–III System (ECM architecture & biomechanical quality)
Dermal mechanical properties depend primarily on Collagen Type I (tensile strength) and Collagen Type III (elastic network support). The DermalGen™ system (Homologous Collagen Type I & III) supports ECM structural organization. In parallel, the amino-acid pool (notably glycine, proline, lysine, hydroxyproline precursors) provides substrate conditions relevant to collagen turnover and matrix maintenance, supporting elasticity, texture, and dermal quality.Dermal nutrition and cellular metabolism support (Complexia Forte 55™)
Complexia Forte 55™ provides a dense nutrient system—amino acids, vitamins, nucleosides, and coenzymes—supporting high-turnover skin biology (keratinocytes/fibroblasts). Coenzymes (NAD/NADP, FAD, Thiamine diphosphate, Coenzyme A) support mitochondrial energy metabolism, enzymatic flux, and redox biochemistry required for cellular function. Nucleosides/nucleotides support DNA/RNA salvage pathways and turnover demands, relevant after microneedling where metabolic requirements increase during recovery. Retinyl Palmitate (Vit. A) supports signaling conditions associated with dermal matrix homeostasis, while B-vitamin complex supports epidermal and dermal metabolic activity.Redox control and macromolecule protection (Dual Antioxidant System + 3OAA)
Glutathione + α-Lipoic Acid provide complementary antioxidant support, helping maintain intracellular thiol balance and redox cycling. 3OAA contributes to the broader redox-support network, supporting oxidative balance in the dermal microenvironment and helping preserve membrane lipids and structural proteins from oxidative stress–associated degradation.
Professional application context
With mesotherapy (papillary dermis targeting) and microneedling (microchannel delivery), actives are placed closer to viable keratinocytes, fibroblasts, and ECM, supporting a multi-pathway skin-quality approach under physician-led protocols.
Physician Summary – Clinical positioning
BelleRevita peptide® is an appropriate first-choice option when the primary goal is intensive hydration plus dermal nutrition—particularly in patients with dehydration, reduced turgor, barrier fragility, dullness, and early skin-quality decline. Its multi-pathway design supports ECM hydration (Hyaluronic Acid), collagen I–III structural organization (DermalGen™), barrier performance, and metabolic/redox balance (Complexia Forte 55™ + antioxidants), making it well suited for mesotherapy and microneedling skin-quality protocols.
BelleRevita peptide® is the regenerative bioactive solution for deep hydration and barrier repair. Contact Persebelle to enrich your treatment portfolio.
