BelleXO® – Regenerative Bioactive Solution for Skin Vitality & Hair Renewal
BelleXO®
BelleXO® is a multi-exosome formulation developed for high-performance regenerative aesthetic treatments.
It combines bioactive extracellular vesicles from a proprietary stem-like cell platform with plant-derived exosomes isolated from the callus tissue of Zingiber officinale, Centella asiatica, and Camellia sinensis. Through regenerative microRNAs, growth factors, and antioxidant phytocompounds, BelleXO® enhances intercellular communication, restores tissue balance, and supports both dermal rejuvenation and follicular renewal.
Developed with TruActive™ preservative-free technology, this lyophilized system preserves the full biological integrity of exosomal content, enabling visible regeneration and long-term vitality in skin and hair tissues.
KEY BENEFITS
Targets skin aging by stimulating collagen and elastin synthesis.
Painless beauty designed for luxury professional treatments.
Revitalizes hair follicles through stem cell activation.
Safe, sterile, with trueActive tecnology
Boosts cellular communication for holistic regeneration.
Shields cells from aging by reducing oxidative stress and restoring mitochondrial balance
SCIENTIFIC FOUNDATION
BelleXO® merges advanced regenerative science with a refined trio of plant-derived extracellular vesicles and bioengineered exosomes. This synergy supports cellular communication and revitalizes tissue function.
Its multi-targeted mechanism helps reduce inflammation, rebalance oxidative stress, and activate fibroblasts for collagen and elastin synthesis.
By strengthening the dermal matrix and skin barrier, BelleXO® enhances hydration, firmness, and long-term skin and scalp vitality.
HOW IT WORKS
Inhibits NF-κB cytokines to reduce chronic inflammation.
Activates fibroblasts for collagen, elastin, and GAGs synthesis.
Upregulates VEGF for angiogenesis and nutrient delivery.
Stimulates dermal papilla cells for prolonged anagen phase.
For professionals
BelleXO® is developed for clinics and aesthetic professionals seeking the next generation in regenerative care. Developed under pharmaceutical-grade standards, its sterile formulation, powered by TruActive™ preservative-free technology, ensures exceptional safety, purity, and efficacy.
Designed for visible results in both skin rejuvenation and hair revitalization, BelleXO® represents a premium opportunity for professionals committed to excellence.
Ingredients
Main actives:
Plant-Derived Exosome Complex:
- Zingiber officinale (Ginger)
- Centella asiatica (CICA)
- Camellia sinensis (Green Tea)
Regenerative Exosomes:
- Defined extracellular vesicles (30–150 nm)
- IGF-binding proteins
- TGF-beta superfamily ligands
- FGF-like mitogens
- TIMPs (Tissue Inhibitors of Metalloproteinases)
- MMP modulators
- Functional microRNAs: miR-21, miR-29, let-7 family
Indications
BelleXO® is a bioengineered regenerative formulation indicated for the treatment of dermal aging, hair follicle dysfunction, and post-procedural tissue stress. By modulating oxidative damage, inflammatory cascades, and mitochondrial instability at a cellular level, it promotes structural restoration and homeostasis of the skin and scalp microenvironments.
Clinical Indications
- Cutaneous aging and dysfunction
- Chronoaging and photoaging phenotypes
- Oxidative and environmental stress-induced degradation
- Epidermal barrier compromise
- Pigmentary irregularities and post-inflammatory hyperpigmentation (PIH)
- Fibroblast senescence and ECM remodeling deficits
- Scalp and follicular disorders
- Androgenetic alopecia (AGA)
- Telogen effluvium (TE)
- Inflammatory-mediated hair loss
- Follicular stem cell quiescence and miniaturization
- Post-procedural recovery
- Optimizes recovery and minimizes inflammation following:
- Ablative and non-ablative laser treatments
- Radiofrequency (RF) microneedling
- PRP, mesotherapy, and ultrasound-based therapies
- Medium to deep chemical peels
Target Application Areas
- Facial dermis: face, neck, and décolleté
- Scalp: as part of regenerative trichology protocols
- Dorsal hands and photodamaged extremities
- Body areas undergoing aesthetic or energy-based procedures
Professional Use Protocol
BelleXO® is intended for use by qualified professionals within medical-aesthetic frameworks. Application must be performed under sterile conditions and integrated into protocols requiring advanced regenerative biotechnologies.
Medical INFO
Mechanism of Action and Scientific Basis:
BelleXO® is a regenerative exosome formulation composed of highly defined extracellular vesicles (30–150 nm) derived from plant callus cultures (Zingiber officinale, Centella asiatica [CICA], Camellia sinensis) and a proprietary stem-like cell platform.
These nanovesicles deliver a bioactive cargo that includes:
- Functional microRNAs (miR-21, miR-29, let-7 family)
- Growth factors (VEGF, IGF-1, TGF-β, HGF)
- ECM-modulatory proteins and FGF-like mitogens
- Redox and inflammatory mediators
This multi-targeted molecular activity contributes to:
Activation of fibroblasts and dermal remodeling
Induction of angiogenesis via VEGF/HIF-1α pathways
Suppression of inflammatory cytokines (e.g., TNF-α, IL-1β)
Restoration of mitochondrial function and redox balance
Protection against UV-induced DNA damage and cellular senescence
Technology and Safety
BelleXO® is produced using TruActive™ preservative-free technology, which ensures the biological viability of the vesicles by avoiding stabilizers, animal derivatives, antibiotics, and serum proteins. Each vial contains a standardized and rigorously quantified nanoparticle concentration, validated by Nanoparticle Tracking Analysis (NTA), ensuring reproducibility and clinical performance.
Professional Administration
Intended exclusively for professional aesthetic use. BelleXO® is applied via microneedling, electroporation, or topical use following barrier-disruptive interventions (e.g., fractional laser, RF, or chemical peels). Administration should follow strict aseptic protocols and be performed under medical supervision.
Presentation and Preparation
Supplied as a sterile, lyophilized powder in 6 ml borosilicate vials. Reconstitute with 3 ml of sterile Water for Injection (WFI) immediately prior to use to maintain optimal nanovesicle structure and activity.
Scientific Summary for Physicians
BelleXO® delivers a next-generation regenerative signal through a dual-origin exosome system: plant-derived nanovesicles from callus tissue (Zingiber officinale, Centella asiatica [CICA], Camellia sinensis) and bioengineered stem-like cell vesicles. Its active cargo—rich in miRNAs, growth factors, and redox modulators—restores cellular communication, reverses signs of aging, and reactivates skin and scalp tissue function. Powered by TruActive™ preservative-free technology.
BelleXO® is the future of aesthetic bioactive solutions – painless, regenerative, and powered by advanced dual-exosome technology. Contact Persebelle to bring this innovation into your professional treatments.
