BelleHair Filler – Regenerative Bioactive Solution for Hair, Healthier Hair
BelleHair Filler
BelleHair Filler peptide® is an advanced bioactive formulation designed to revitalize hair and scalp health.
Powered by regenerative science, it activates follicular stem cells, enhances nutrient delivery, and strengthens hair shafts from the root.
This painless beauty solution supports density, vitality, and long-lasting resilience, offering professionals a next-generation approach to hair restoration.
KEY BENEFITS
Stimulates follicular activity for stronger growth.
Comfort-focused, painless beauty experience.
Enhances scalp vitality and microcirculation.
Reduces triggers of hair loss and DHT activity.
Improves anchorage and hair density.
SCIENTIFIC FOUNDATION
BelleHair Filler peptide® integrates bioengineered peptides and regenerative actives to restore scalp balance and re-energize hair follicles.
By aligning with cellular communication pathways and modulating inflammatory responses, it ensures both short-term visible improvements and long-term follicle preservation
HOW IT WORKS
Activates Wnt/β-catenin and IGF-1 signaling to prolong growth phase.
Promotes VEGF expression for angiogenesis and nutrient supply.
Stimulates extracellular matrix renewal for stronger follicles.
Inhibits pro-inflammatory cytokines and reduces 5α-reductase activity.
For professionals
BelleHair Filler peptide® is designed exclusively for clinics and professionals seeking luxury regenerative hair solutions.
Its sterile TruActive TM, formulation and pharmaceutical-grade standards ensure safety and unmatched efficacy in aesthetic bioactive solutions.
Ingredients
72 active ingredients designed to support hair regeneration and follicle vitality.
Trichogen™
Copper Tripeptide-1, Octapeptide-2, Biotinyl Tripeptide-1, Acetyl Tetrapeptide-3, Oligopeptide-71, Decapeptide-28
Androgen Regulation
5-α-reductase inhibitor: Biochanin A
Hydration & Matrix Support
Complexia 55™, Hyaluronic Acid
Stem Cell Activation
Ecklonia, Carthamus, Ishige, Adenosine
Growth Factor Modulation
TGF-β1 down-regulator: Apigenin
Microcirculation Support
Rutin
Antioxidant Protection
Glutathione, 3-OAA
Indications
HAIR LOSS AND FOLLICULAR REGENERATION
BelleHair Filler peptide® is indicated for the treatment and prevention of hair loss in both men and women, supporting hair regeneration and follicular vitality.
Main indications include:
- Androgenic Alopecia
- Hair thinning and progressive loss of density
- Reduced hair volume
- Hair follicle fragility
- Follicular conditions associated with inflammatory or oxidative stress
Treatment areas include the temples and crown. In general, BelleHair Filler peptide® may be applied to any scalp area presenting hair thinning or loss, as well as in preventive treatment protocols.
The use of BelleHair Filler peptide® requires medical supervision.
Medical INFO
BelleHair Filler peptide® provides bioactive substrates that support prostaglandin synthesis, a key regulatory mechanism in androgen signaling within the hair follicle.
In hair cycle biology, follicular homeostasis depends on the balance between positive and negative regulatory factors. BelleHair Filler peptide® promotes the synthesis of key growth factors, including insulin-like growth factor-1 (IGF- 1), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF), supporting follicular regeneration and maintaining the hair follicle in the anagen phase.
The formulation addresses the critical crosstalk between androgen signaling and the WNT/β-catenin pathway, a central axis in hair follicle development and cycling.
Selected bioactive ingredients have demonstrated significant in vitro activity, in some cases comparable to reference molecules such as minoxidil and finasteride.
Clinical application over a six month period supports an active anagen state, with only approximately 10–15% of follicles remaining in the telogen phase. This results in improved hair growth, stronger follicular anchoring, enhanced microcirculation, and increased hair density.
BelleHair Filler peptide® exerts its activity through multiple synergistic mechanisms:
1. Inhibition of BMP signaling, restoring activation of the WNT/β-catenin pathway.
2. Regulation of key growth factors involved in stem cell activation, including FGF-7, FGF-10, TGF-β2, and Noggin (NOG).
3. Stimulation of adipocyte precursor cells (APCs) within the adipose tissue, increasing platelet-derived growth factor (PDGF) production, a critical mediator of stem cell activation.
4. Effective inhibition of 5-α reductase activity via Biochanin A, leading to downregulation of dihydrotestosterone (DHT), a central factor in androgenetic hair loss.
5. Activation of Bcl-2 signaling pathways, promoting mTOR-mediated hair growth gene expression while inhibiting pro-apoptotic proteins such as Bax and BH3, thereby supporting follicular cell survival.
6. Enhancement of microcirculation through increased VEGF synthesis, promoting angiogenesis and improved nutritional support to the dermal papilla.
BelleHair Filler peptide® is manufactured using aseptic filling techniques to preserve the integrity of all bioactive components. The formulation is sterile and preservativefree through TruActive™ technology, making it suitable for use in a wide range of professional aesthetic protocols, including microneedling, roller systems, IPL-assisted treatments, and other invasive or non-invasive medical aesthetic procedures.
BelleHair Filler peptide® is the painless, regenerative solution for hair vitality. Contact Persebelle to bring the next generation of bioactive beauty to your practice.
