FaceBotolift – Regenerative Bioactive Solution for Expression Line Relaxation
FaceBotolift
FaceBotolift peptide® is a peptide-based solution that mimics botulinum-like action to reduce expression lines.
It smooths dynamic wrinkles, relaxes muscle tension, and restores a youthful appearance. Designed as a painless alternative, it provides patients with natural and subtle results.
KEY BENEFITS
Reduces dynamic wrinkles and expression lines.
Safe, painless, and ideal for professional use.
Relaxes facial tension for smoother skin.
Improves skin elasticity and firmness.
Provides a lifting effect without invasive procedures.
SCIENTIFIC FOUNDATION
FaceBotolift peptide® acts through peptides that mimic botulinum mechanisms, modulating neurotransmitter release at neuromuscular junctions.
This relaxes facial micro-contractions while supporting dermal renewal, resulting in smoother skin.
HOW IT WORKS
Mimics botulinum-like action to relax micro-contractions.
Smooths dynamic wrinkles and expression lines.
Provides a lifting and rejuvenated skin effect.
Supports dermal collagen renewal for elasticity.
For professionals
FaceBotolift peptide® offers distributors and medical professionals a next-generation, Botox-like solution for expression line relaxation, backed by advanced neuromodulating science and pharmaceutical-grade quality.
A differentiated product designed for modern aesthetic practices, FaceBotolift combines medical credibility with strong market demand.
Ingredients
Main actives:
Liftimax LF5™
Octapeptide-3, Hexapeptide-8, Hexapeptide-30,
Pentapeptide-3, DDBA
GABA
Indications
FaceBotolift peptide® is indicated for the treatment of dynamic facial expression lines caused by repetitive mimetic muscle activity, where a Botox like neuromodulating effect on facial muscle contraction is clinically desired, while preserving natural facial expression.
Primary indications
- Dynamic expression lines of the upper and mid face, including forehead lines, glabellar lines and periorbital expression lines (crow’s feet).
- Early to moderate expression lines associated with increased neuromuscular activity.
- Patients requiring controlled relaxation of facial muscle dynamics to improve the appearance of expression lines.
Clinical positioning
- First-choice treatment for physicians seeking a Botox-like peptide-based solution for expression line relaxation.
- Suitable for patients in whom a progressive, controlled, and expression-respecting neuromodulating effect is
indicated. - Can be incorporated into aesthetic treatment protocols focused on management and prevention of expression line progression.
Treatment areas
Face and neck, according to clinical assessment.
Professional use
The application of FaceBotolift peptide® requires medical supervision.
Medical INFO
FaceBotolift peptide® is a bioactive formulation designed to induce a Botox-like relaxation of facial expression muscles through a multi pathway neuromodulating mechanism, while preserving physiological muscle function and natural facial expression.
The clinical effect of FaceBotolift is primarily mediated by Liftimax LF5™, supported by GABA, and is based on the simultaneous modulation of acetylcholine release, acetylcholine receptor activation, neuronal excitability, and neuromuscular junction organization, with secondary supportive effects on dermal structural integrity.
1. Modulation of acetylcholine release (presynaptic action) Liftimax LF5™ modulates neuromuscular transmission at the presynaptic level by interfering with the molecular machinery responsible for acetylcholine (ACh) release. By competitively inhibiting SNARE complex assembly, it reduces vesicular fusion and down regulates synaptic acetylcholine availability at the neuromuscular junction, resulting in controlled reduction of facial muscle activation.
2. Inhibition of acetylcholine receptor activation (postsynaptic action) Liftimax LF5™ exerts a postsynaptic neuromodulating effect by reversibly inhibiting nicotinic acetylcholine receptors on the muscle end plate, reducing ion channel opening, membrane depolarization and muscle responsiveness to acetylcholine stimulation.
3. Modulation of neuronal excitability
Liftimax LF5™ modulates neuronal excitability through pathways related to endogenous enkephalins, reducing neuronal firing frequency and catecholamine release, thereby contributing to global down-regulation of neuromuscular stimulation.
4. Inhibition of neuromuscular junction organization (MuSK pathway)
Liftimax LF5™ interferes with MuSK-mediated signaling, reducing acetylcholine receptor clustering and neuromuscular transmission efficiency, supporting durable modulation of facial muscle dynamics.
5. GABA-mediated neuromodulatory reinforcement GABA induces neuronal membrane hyperpolarization and reduces calcium channel activity, further suppressing acetylcholine release and reinforcing the neuromodulating action of Liftimax LF5™.
6. Secondary effects on dermal structural integrity
FaceBotolift influences dermal architecture by upregulating fibrillin-1, fibrillin-5 and integrins, increasing proteoglycan synthesis and inhibiting matrix metalloproteinases (MMPs), thereby improving dermal cohesion and epidermal dermal junction morphology.
FaceBotolift peptide® is the regenerative bioactive solution for expression line relaxation. Contact Persebelle to expand your anti-aging treatments.
