BelleDonna – Regenerative Bioactive Solution for Brightening & Even Skin Tone
BelleDonna
BelleDonna® is a professional brightening solution developed to reduce pigmentation and improve uneven skin tone.
Through a bioactive, multi-pathway formulation combining targeted peptides with depigmenting and antioxidant actives, it helps regulate melanin production, enhance skin radiance, and promote a clearer, more uniform complexion. Designed for painless professional protocols.
KEY BENEFITS
Reduces hyperpigmentation and dark spots.
Safe, painless, and suitable for professional use.
Balances melanin synthesis for even skin tone.
Enhances skin luminosity and radiance.
Protects skin from oxidative stress.
SCIENTIFIC FOUNDATION
BelleDonna peptide® is powered by brightening peptides that regulate tyrosinase activity and melanin transfer.
It reduces oxidative damage while stimulating cellular renewal, helping restore balanced pigmentation and luminous skin.
HOW IT WORKS
Regulates melanin synthesis at cellular level.
Inhibits tyrosinase activity to reduce spots.
Supports antioxidant defense against free radicals.
Enhances clarity and brightness of complexion.
For professionals
BelleDonna peptide® is developed for professionals seeking effective pigmentation-balancing solutions. Its pharmaceutical-grade formulation ensures visible results with safety and consistency.
Ingredients
Main Actives:
Lumyra™
AGβA (Acetyl-Glycyl-β-Alanine) , Decapeptide-15, Oligopeptide-68, Oligopeptide-34, Oligopeptide-51, Oligopeptide-58.
α-Arbutin, Glutathione, Glabridin, (3OAA)and Niacinamide.
Hyaluronic Acid in a specialized combination of molecular weights.
Enhanced with Complexia 55™, a plasma-like nutrient-rich complex.
Indications
BelleDonna peptide® – Professional Skin Brightening & Tone Correction
Main indications:
- Uneven skin tone and pigmentation irregularities
- Appearance of hyperpigmentation and localized dark spots
- Lentigines and sun-related pigmentation marks
- Melasma-prone skin, within controlled professional protocols
- Loss of skin luminosity and visual clarity
Treatment areas:
Face, neck, décolleté, and back of the hands
Professional use:
BelleDonna peptide® is intended for use by qualified medical or aesthetic professionals under professional supervision.
Medical INFO
Mechanism of Action – Multi-Pathway Control of
Pigmentation
BelleDonna peptide® is formulated to act on the key biological mechanisms involved in pigmentation dysregulation. Its activity is based on a multi-pathway approach targeting melanin synthesis, melanosome formation and transfer, receptor activation, and oxidative stress.
1. Inhibition of Tyrosinase Activity and Regulation
The Lumyra™ peptide complex, together with α-Arbutin, Glabridin, Glutathione, and 3OAA, interferes with tyrosinase activity by disrupting copper-mediated catalytic function and interacting with residues near the catalytic core.
2. Interference with Melanosome Formation, Maturation, and Transfer Niacinamide modulates PAR-2, AGβA inhibits melanophilin, and selected oligopeptides interfere with melanosome formation and maturation, reducing melanin transfer.
3. Modulation of Melanin Synthesis via MITF Control
Specific peptides block MC1R, SCF, and WNT signaling, suppressing MITF-mediated melanogenesis.
4. Inhibition of MC1R Activity AGβA and 3OAA block α-MSH signaling, preventing downstream melanogenic activation.
5. Antioxidant Control of Intracellular Redox State Glutathione and 3OAA reduce UV-induced oxidative stress and limit melanogenic activation.
Formulation & Clinical Integration Manufactured using aseptic filling technology. Sterile and formulated with TrueActive technology (no preservatives). Suitable for mesotherapy, microneedling, roller, IPL, and other professional aesthetic protocols.
BelleDonna peptide® is the regenerative bioactive solution for brightening and pigment balance. Contact Persebelle to integrate advanced whitening innovation into your clinic.
