For Hair Applications:
Androgenetic alopecia (AGA) in men and women
Diffuse hair thinning and reduced hair density
Follicular miniaturization and loss of tensile strength
Oxidative or inflammatory damage to the scalp environment
As a preventive protocol to maintain follicular health
Treatment areas: Frontal scalp, temples, crown (vertex), and any region exhibiting signs of alopecia or early degeneration.
For Skin Applications:
Photoaged or chronically inflamed skin
Atrophic or collagen-deficient dermis
Post-procedural regeneration (e.g., laser, microneedling, RF)
Acne scars, superficial fibrosis, or compromised wound healing
Loss of skin elasticity, texture, or tone
Treatment areas: Face, neck, décolleté, or any skin zone requiring bio-repair.
The application of BelleXO® must be performed under medical supervision by professionals trained in regenerative protocols.
A multi-source exosome system delivering regenerative signaling molecules and antioxidant phytocompounds. Regenerative Cell Line-Derived Exosomes. Concentration: ~6 × 10⁹ particles per vial. microRNAs: miR-21, miR-146a, miR-125b. Growth factors: TGF-β1, VEGF, IGF-1. Cytokine analogs: IL-10, HGF. Surface markers: CD63, CD81, CD9. Zingiber officinale-Derived Exosomes. Concentration: ~6 × 10⁹ particles per vial. 6-Gingerol. 6-Shogaol. Zingerone. Centella asiatica-Derived Exosomes. Concentration: ~6 × 10⁹ particles per vial. Asiaticoside. Madecassoside. Asiatic acid. Camellia sinensis-Derived Exosomes. Concentration: ~6 × 10⁹ particles per vial. EGCG. Catechins. Polyphenols. Plant-derived modulators of NF-κB, TGF-β, and MAPK pathways. Potent ROS scavengers and mitochondrial protectors. BelleXO® is 100% xenobiotic-free, with no animal derivatives, antibiotics, or proteins from fetal bovine serum (FBS). Each vial contains a standardized nanoparticle concentration, rigorously quantified by Nanoparticle Tracking Analysis (NTA).
BelleXO® provides a targeted regenerative signal platform using purified extracellular vesicles (exosomes) derived from a lab-cultured regenerative cell line and three phytogenic sources: Zingiber officinale, Centella asiatica, and Camellia sinensis. These exosomes deliver molecular cargo (microRNAs, growth factors, and antioxidant phytochemicals) capable of modulating key biological pathways in both skin and hair tissue degeneration.
In scalp biology, BelleXO supports Anagen maintenance and re-entry by upregulating IGF-1, VEGF, and bFGF, while suppressing inflammatory mediators like TNF-α and IL-6. Follicular stem cell activity is reactivated via WNT/β-catenin restoration, while the androgenic microenvironment is balanced through indirect DHT modulation by plant miRNAs and gingerols. Centella asiatica adds further stimulation of ECM components, and Camellia sinensis reinforces follicular antioxidant protection and mitochondrial preservation.
In dermal tissue, BelleXO enhances extracellular matrix synthesis (collagen I & III), inhibits matrix metalloproteinases (MMPs), and reactivates senescent fibroblasts via epigenetic and paracrine reprogramming. Exosomal catechins and triterpenoids stabilize mitochondrial function and suppress ROS accumulation — both central drivers of dermal aging.
Documented Biological Effects Include:
• Upregulation of regenerative cytokines: VEGF, HGF, TGF-β1 analogs
• Restoration of WNT/β-catenin via BMP inhibition
• Stimulation of dermal stem cell niches: FGF-7, FGF-10, PDGF pathways
• Anti-DHT signaling via upstream redox and inflammation modulation
• Activation of the mTOR pathway (↑ Bcl-2, ↓ Bax) for cell survival
• Increased microcirculation via VEGF and nitric oxide signaling
BelleXO® is produced via a closed aseptic lyophilization process, ensuring the sterility, structural integrity, and biological viability of all vesicular components. The product is preservative-free, endotoxin-free, and suitable for use with microneedling, RF, PRP, ultrasound, or laser-based aesthetic protocols, both invasive and non-invasive.
