FIRMING peptide® has an extraordinary effect boosting the synthesis of the 4 main group of substances to maintain the cohesion of the skin avoiding sagging and flaccidity: collagen fibbers, adhesion proteins, elastin fibbers and integrins.
FIRMING peptide® shows remarkable effect on the following:
1.- Enhances tonicity of the underlying facial muscles tightening the skin.
2.- Increase of Collagen fibbers especially collagen Type I, also IV, VI and XIV. Increases the relation collagen Type I/III.
3.- Adhesion proteins include multiprotein complex like Talin and Paxillin.
4.- Up regulates synthesis of Elastin fibbers, Tropoelastin, Fibuline-5, Fibrillin-1 and LOX-1.
5.-Enhance synthesis of integrin.
Promoting of the cohesion between Extra-Cellular Matrix and Fibroblasts by up-regulation of Fibuline-5, Fibrilin-1 and Integrin. The non adhesion of Fibroblasts with the Collagen and Elastin is very important to explain the signs of skin sagging.
After a few sessions of FIRMING peptide® the skin shows the following:
1.- The stratum corneum stars to recover its flaky appearance.
2.- The Dermal Epidermal Junction goes to wavy instead to flat.
3.- The thickness of the Epidermis increases.
4.- Dermis recovery by the amount of collagen and elastin fibbers showing up regulation of their synthesis and inhibition of Metalloproteinase, especially MMP-1.
FIRMING peptide® is manufactured using aseptic filling technique under lyophilized presentation in sterile, preservative free and pyrogen free conditions and is intended to be used on several aesthetic techniques, roller, IPL, and other invasive or non-invasive procedures.